People with CF have inherited two copies of the defective CF gene - one copy from each parent. For this reason, avoiding germs is a top concern for people with CF.Ĭystic fibrosis is a genetic disease. In the lungs, the mucus clogs the airways and traps germs, like bacteria, leading to infections, inflammation, respiratory failure, and other complications. Without the chloride to attract water to the cell surface, the mucus in various organs becomes thick and sticky. When the protein is not working correctly, it’s unable to help move chloride - a component of salt - to the cell surface. In people with CF, mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the CFTR protein to become dysfunctional. Learn the facts on our page, Dispelling Misconceptions About Cystic Fibrosis. There are close to 40,000 children and adults living with cystic fibrosis in the United States (and an estimated 105,000 people have been diagnosed with CF across 94 countries), and CF can affect people of every racial and ethnic group. Cystic fibrosis is a progressive, genetic disease that affects the lungs, pancreas, and other organs.
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